Understanding how DMBT1 suppression affects the spread of oral cancer
Exploring the Role of DMBT1 Suppression in Invasion of Oral Cancer
This study is looking at how the most common type of oral cancer, squamous cell carcinoma, spreads in the body and how a specific protein that usually helps stop tumors from growing is affected by signals from cancer cells, with the hope that this will lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10908250 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which squamous cell carcinoma (SCC), the most common form of oral cancer, invades surrounding tissues, leading to recurrence and poor survival rates. The study focuses on the role of a tumor suppressor protein called DMBT1, which is downregulated in SCC, and how this suppression is influenced by transforming growth factor-beta (TGFβ) secreted by cancer cells. By examining the interactions between cancer cells and nearby non-cancerous cells, known as cancer-associated keratinocytes (CAKs), the research aims to uncover new insights into cancer invasion and potential therapeutic targets. Patients may benefit from a better understanding of how oral cancer spreads, which could lead to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with squamous cell carcinoma of the oral cavity.
Not a fit: Patients with other types of oral cancers or those who are not currently undergoing treatment for SCC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that reduce the recurrence of oral cancer and improve patient survival.
How similar studies have performed: Previous studies have shown that understanding the interactions between cancer cells and their microenvironment can lead to significant advancements in cancer treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Danella, Erika Bunnine — University of Michigan at Ann Arbor
- Study coordinator: Danella, Erika Bunnine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.