Understanding how distant gene enhancers control gene activity
Deciphering the mechanism of long-range gene regulation in vivo
This study is looking at how certain parts of our DNA, called enhancers, help control genes from far away during the development of mammals, like mice, and it hopes to find out how changes in these enhancers might be linked to human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10473041 on NIH RePORTER |
What this research studies
This research investigates how remote transcriptional enhancers, which are regions of DNA that can influence gene expression from a distance, regulate target genes during mammalian development. By using advanced techniques in mice, the study aims to identify the sequences and mechanisms that enable these enhancers to communicate with genes over long genomic distances. This approach seeks to overcome limitations of traditional methods that have not fully explored long-range enhancer activity. The findings could provide insights into how mutations in these enhancers may lead to human diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that may be linked to mutations in enhancer regions of their DNA.
Not a fit: Patients with conditions not related to genetic mutations affecting enhancer activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic diseases linked to enhancer mutations, potentially paving the way for new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through enhancer activity, indicating that this approach has potential for significant discoveries.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kvon, Evgeny — University of California-Irvine
- Study coordinator: Kvon, Evgeny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.