Understanding how disruptions in cellular machinery contribute to dementia.
Official title: Disruptions to nuclear proteostasis machinery as drivers of neurodegeneration in dementia.
Funded at University of Washington · NIH-10973065 · Data updated 2026-11-12
This study is looking at how problems with protein management in brain cells might lead to Alzheimer's and similar diseases in people over 65, with the goal of finding new ways to help slow down or prevent these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $50,474 |
| NIH project number | 1F99AG088436-01 |
| Project ID | NIH-10973065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of dementia or are at risk for developing Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without any signs of neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the role of nuclear proteostasis machinery in neurodegenerative diseases like Alzheimer's and frontotemporal lobar degeneration, particularly in individuals aged 65 and older. It aims to uncover how disruptions in cellular processes, such as protein aggregation and transport within neurons, contribute to the development of dementia. By studying these mechanisms, the research seeks to identify potential targets for therapeutic intervention that could slow or prevent neurodegeneration. The approach includes using model organisms to explore genetic factors and their impact on disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of dementia and improve the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of cellular mechanisms in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Eck, Randall — University of Washington
- Study coordinator: Eck, Randall
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.