Understanding how disrupted lipid metabolism affects Alzheimer's disease
Official title: Disrupted Lipid Metabolism in Alzheimer's Disease
Funded at University of Arizona · NIH-10884782 · Data updated 2026-11-12
This study is looking at how the way our brain cells handle fats might affect Alzheimer's disease, with the hope of finding new ways to help people manage their symptoms and improve their brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,610,885 |
| NIH project number | 1RF1AG079157-01A1 |
| Project ID | NIH-10884782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic or lifestyle factors.
✕Less likely to help
Patients with other forms of dementia unrelated to lipid metabolism may not receive benefit from this research.
What this research studies
This research investigates the role of lipid metabolism in Alzheimer's disease, focusing on how changes in fatty acid processing in brain cells, particularly astrocytes, may contribute to the onset and progression of the disease. By examining the mechanisms behind lipid dysregulation, the study aims to uncover potential pathways that lead to neuroinflammation and cognitive decline associated with Alzheimer's. Patients may benefit from insights gained into how lipid metabolism influences their condition, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting lipid metabolism to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has indicated that targeting lipid metabolism may have therapeutic potential in neurodegenerative diseases, suggesting a promising avenue for further exploration.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Yin, Fei — University of Arizona
- Study coordinator: Yin, Fei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.