Understanding how disrupted hormone rhythms affect breast cancer outcomes
Official title: Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer
Funded at Cold Spring Harbor Laboratory · NIH-10780760 · Data updated 2026-11-12
This study is looking at how changes in a hormone called cortisol might affect breast cancer patients' health and survival, and it aims to find new ways to help by restoring normal hormone levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $456,048 |
| NIH project number | 1R01CA286651-01 |
| Project ID | NIH-10780760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with breast cancer who exhibit disrupted glucocorticoid hormone rhythms.
✕Less likely to help
Patients with breast cancer who have normal glucocorticoid rhythms may not benefit from this research.
What this research studies
This research investigates the relationship between disrupted glucocorticoid hormone rhythms and breast cancer progression. It focuses on how these hormonal changes, particularly in cortisol levels, impact the quality of life and survival rates of breast cancer patients. By studying the interactions between the hypothalamus, pituitary gland, and adrenal glands, the research aims to uncover mechanisms that could lead to new treatment strategies. The approach includes using preclinical mouse models to explore the effects of restoring normal hormone rhythms on cancer outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance the quality of life and survival rates for breast cancer patients.
How similar studies have gone: Other research has shown that addressing hormonal imbalances can lead to significant improvements in cancer treatment outcomes, suggesting a promising avenue for this investigation.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Borniger, Jeremy — Cold Spring Harbor Laboratory
- Study coordinator: Borniger, Jeremy
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.