Understanding how disordered proteins interact with other molecules
Decoding the mechanism of disordered protein interactions
['FUNDING_OTHER'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-10892943
This study is looking at special proteins that change shape and play important roles in our cells, and by using computer models, researchers hope to learn how these proteins interact with others, which could help find new treatments for diseases caused by protein problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-10892943 on ClinicalTrials.gov |
What this research studies
This research investigates intrinsically disordered proteins (IDPs) that do not have a fixed structure but are crucial for various cellular functions. The project employs advanced computational modeling techniques to explore how these proteins interact with other biomolecules, particularly focusing on their flexible regions and the process of liquid-liquid phase separation. By collaborating with experimental groups, the research aims to provide insights into the dynamics and flexibility of IDPs, which could enhance our understanding of their biological roles. Patients may benefit from the findings as they could lead to new therapeutic strategies for diseases involving protein misfolding or dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding disorders, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein interactions or those not affected by protein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for diseases related to protein misfolding and dysfunction.
How similar studies have performed: Previous research has shown success in understanding protein interactions through computational modeling, indicating that this approach is promising.
Where this research is happening
TEMPE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, WENWEI — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: ZHENG, WENWEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.