Understanding how disordered protein regions function in biology
Official title: Defining the modular architecture of protein intrinsically disordered regions for a predictive understanding of biological function
Funded at Ut Southwestern Medical Center · NIH-10940573 · Data updated 2026-11-12
This study is looking at certain parts of proteins that don't have a fixed shape, to find patterns that could help us understand how they work in the body, which might lead to better treatments and tests for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $337,949 |
| NIH project number | 1R01GM155100-01 |
| Project ID | NIH-10940573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases related to protein misfolding or dysfunction.
✕Less likely to help
Patients with conditions unrelated to protein function or structure may not receive any benefit from this research.
What this research studies
This research investigates the structural characteristics of intrinsically disordered regions (IDRs) in proteins, which do not adopt stable structures like traditional proteins. By developing a statistical algorithm, the study aims to identify patterns in the amino acid composition of these disordered regions, potentially allowing for predictions about their biological functions. The approach combines bioinformatics and structural biology to enhance our understanding of protein functionality, which could lead to new insights in various biological processes. Patients may benefit from advancements in targeted therapies and diagnostics based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases linked to protein dysfunction.
How similar studies have gone: Previous research has shown success in using bioinformatics to understand protein structures, suggesting that this approach may yield valuable insights as well.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Parker, Matthew W. — Ut Southwestern Medical Center
- Study coordinator: Parker, Matthew W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.