Understanding how Disabled-2 affects breast cancer pathways
Official title: Disabled-2 in the metabolic regulation of oncopathways
Funded at Baylor College of Medicine · NIH-10757684 · Data updated 2026-11-12
This study is looking at how a protein called Disabled-2 affects important signals in triple-negative breast cancer, which is a tough type of breast cancer to treat, with the goal of finding new ways to help improve treatment for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 9, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $80,000 |
| NIH project number | 5R03CA277079-02 |
| Project ID | NIH-10757684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with triple-negative breast cancer who may benefit from novel therapeutic approaches.
✕Less likely to help
Patients with hormone receptor-positive breast cancer or other non-TNBC subtypes may not receive direct benefits from this research.
What this research studies
This research investigates the role of Disabled-2 in regulating key signaling pathways involved in triple-negative breast cancer (TNBC), a type of breast cancer known for its aggressive nature and limited treatment options. The study focuses on mitochondrial retrograde signaling and how it influences the phosphorylation of the Src oncogene, which is crucial for tumor growth and metastasis in TNBC. By exploring the mechanisms behind this regulation, the research aims to uncover new therapeutic targets that could improve treatment outcomes for patients with TNBC.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the aggressive pathways in triple-negative breast cancer, potentially improving survival rates.
How similar studies have gone: While the specific role of Disabled-2 in TNBC is being explored for the first time, similar approaches targeting oncogenic pathways have shown promise in other cancer types.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Kaipparettu, Benny Abraham — Baylor College of Medicine
- Study coordinator: Kaipparettu, Benny Abraham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.