Understanding how different vaccine adjuvants work together to enhance immune responses
Defining molecular mechanisms of combination adjuvants: a systems immunology, transcriptomics and imaging approach
This study is exploring how different vaccine boosters can help your immune system fight off illnesses like the flu and COVID-19, using lab tests and animal studies to see how they work with immune cells in your body.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10807969 on NIH RePORTER |
What this research studies
This research investigates the molecular and cellular mechanisms behind various combinations of vaccine adjuvants, which are substances that enhance the body's immune response to an antigen. By using advanced techniques such as high-throughput assays and live cell imaging, the study aims to analyze how these adjuvants interact at the cellular level, particularly focusing on their effects on immune cells like dendritic cells and B cells. The research will involve both laboratory experiments and animal models to evaluate the effectiveness of these combinations in promoting a stronger immune response against specific pathogens, including influenza and SARS-CoV-2.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for infections that could be prevented by improved vaccines, such as those with weakened immune systems or those in high-exposure environments.
Not a fit: Patients who are not at risk for infectious diseases or those who have already received effective vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide better protection against infectious diseases.
How similar studies have performed: Previous research has shown promising results with similar approaches in enhancing vaccine efficacy through the use of combination adjuvants.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Davies, David Huw — University of California-Irvine
- Study coordinator: Davies, David Huw
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.