Understanding how different types of streptococci affect oral infections
Official title: Probing the role of heterogeneity in streptococcal interactions
Funded at Case Western Reserve University · NIH-10841244 · Data updated 2026-11-12
This study looks at how different types of common mouth bacteria interact with harmful germs that can cause oral diseases, hoping to find new ways to improve our understanding of conditions like gum disease, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 8, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $111,972 |
| NIH project number | 3R00DE031018-04S1 |
| Project ID | NIH-10841244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing chronic oral diseases, particularly periodontitis.
✕Less likely to help
Patients with no oral health issues or those not affected by streptococcal-related infections may not benefit from this research.
What this research studies
This research investigates the interactions between various strains of streptococci, which are common bacteria in the mouth, and harmful oral pathogens. By examining how genetic and phenotypic differences among streptococci influence their behavior and the severity of oral diseases, the study aims to uncover new insights into infection dynamics. The research employs advanced techniques to analyze these microbial interactions and their implications for oral health. Patients may benefit from a better understanding of how these bacteria contribute to conditions like periodontitis.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating oral infections.
How similar studies have gone: Previous research has shown that understanding microbial interactions can lead to significant advancements in treating oral diseases, suggesting this approach has potential for success.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Lewin, Gina — Case Western Reserve University
- Study coordinator: Lewin, Gina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.