Understanding how different types of lung blood vessel cells develop and their impact on lung diseases
Mechanism of pulmonary endothelial cell heterogeneity and its role in disease
['FUNDING_OTHER'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10894837
This study is looking at how certain cells in the lungs help form blood vessels and how changes in these cells might lead to lung diseases, like bronchopulmonary dysplasia, with the hope of finding new treatments to improve lung health for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10894837 on ClinicalTrials.gov |
What this research studies
This research investigates the development of blood vessels in the lungs and how variations in these cells can contribute to diseases. The principal investigator, Dr. Lisandra Via Ellis, will explore a specific group of endothelial cells that are crucial for normal lung function and how their absence can lead to conditions like bronchopulmonary dysplasia. By utilizing advanced imaging techniques, the study aims to uncover the mechanisms behind cell differentiation and their roles in lung health and disease. Patients may benefit from insights that could lead to new treatments for lung-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with lung diseases, particularly those under 21 years old, who may be affected by conditions like bronchopulmonary dysplasia.
Not a fit: Patients with lung diseases not related to blood vessel development or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung diseases associated with abnormal blood vessel development.
How similar studies have performed: Previous research has shown promising results in understanding vascular biology and its implications for lung diseases, indicating that this approach has potential for success.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILA ELLIS, LISANDRA — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: VILA ELLIS, LISANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.