Understanding how different types of lung blood vessel cells develop and their impact on lung diseases
Official title: Mechanism of pulmonary endothelial cell heterogeneity and its role in disease
Funded at Northwestern University at Chicago · NIH-10894837 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs help form blood vessels and how changes in these cells might lead to lung diseases, like bronchopulmonary dysplasia, with the hope of finding new treatments to improve lung health for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL155845-04 |
| Project ID | NIH-10894837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with lung diseases, particularly those under 21 years old, who may be affected by conditions like bronchopulmonary dysplasia.
✕Less likely to help
Patients with lung diseases not related to blood vessel development or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the development of blood vessels in the lungs and how variations in these cells can contribute to diseases. The principal investigator, Dr. Lisandra Via Ellis, will explore a specific group of endothelial cells that are crucial for normal lung function and how their absence can lead to conditions like bronchopulmonary dysplasia. By utilizing advanced imaging techniques, the study aims to uncover the mechanisms behind cell differentiation and their roles in lung health and disease. Patients may benefit from insights that could lead to new treatments for lung-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung diseases associated with abnormal blood vessel development.
How similar studies have gone: Previous research has shown promising results in understanding vascular biology and its implications for lung diseases, indicating that this approach has potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Vila Ellis, Lisandra — Northwestern University at Chicago
- Study coordinator: Vila Ellis, Lisandra
Related research
Other NIH-funded projects on the same topics.
-
High-intensity exercise as a treatment for Parkinson's disease
This study is looking at whether doing high-intensity endurance exercise can help people who have just been diagnosed with Parkinson's disease feel better and slow down their symptoms, especially since current medications don't always do the trick.
-
Software to quickly assess organ dose after radionuclide exposure
This study is creating a helpful software tool that quickly calculates how much radiation your organs absorb after you've taken certain radioactive substances, so you can get better care and treatment based on your individual needs.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for better ways to improve your care and treatment, so you can get more personalized options that work best for you.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for new ways to improve care and treatment for patients, and if you join, you might help test some exciting new methods that could lead to better health for everyone.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for ways to improve care and treatment for patients like you, by trying out new methods that could help manage your health better.
-
Investigating core biological processes
This study is all about exploring important biological processes that affect our health, and it invites patients to help discover new ways to improve care for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.