Understanding how different types of immune cells in tumors affect cancer treatment
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
This study is looking at how a type of immune cell called macrophages behaves in non-small cell lung cancer, with the hope of finding new ways to help patients respond better to treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11013371 on NIH RePORTER |
What this research studies
This research investigates the diverse roles of macrophages, a type of immune cell, within tumors, particularly in non-small cell lung cancer. By using advanced techniques like mass cytometry and single-cell RNA sequencing, the study aims to identify various macrophage populations and their functions in the tumor microenvironment. The goal is to understand how these immune cells influence tumor growth and response to immunotherapy, which could lead to new treatment strategies for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those not diagnosed with lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by targeting specific macrophage populations to enhance the immune response against tumors.
How similar studies have performed: Other research has shown promise in targeting immune cells for cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Merad, Miriam — Icahn School of Medicine at Mount Sinai
- Study coordinator: Merad, Miriam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.