Understanding how different types of immune cells affect C. difficile infections
Official title: Impact of neutrophil heterogeneity on pathogenesis of C. difficile infection
Funded at Cincinnati VA Medical Center Research · NIH-10917739 · Data updated 2026-11-12
This study is looking at how a type of immune cell called neutrophils affects people with Clostridium difficile infections, aiming to find out what helps or harms recovery, so we can create better treatments that focus on the body's immune response.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati VA Medical Center Research NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2019 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| NIH project number | 2I01BX004630-06 |
| Project ID | NIH-10917739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Clostridium difficile infections.
✕Less likely to help
Patients who do not have C. difficile infections or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the outcomes of Clostridium difficile infections (CDI). The team aims to identify both harmful and helpful host factors that influence disease progression, focusing on how neutrophils contribute to inflammation and intestinal damage during CDI. By using advanced techniques like single cell transcriptomics, they are mapping the behavior of neutrophils in the blood and intestines of patients with CDI. The ultimate goal is to develop new therapies that target the host's immune response rather than just the bacteria itself.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve recovery and outcomes for patients suffering from C. difficile infections.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in infections, suggesting that this approach could yield significant insights.
Where this research is happening
-
Cincinnati VA Medical Center Research
Cincinnati, United States Active
Researchers
- Principal investigator: Madan, Rajat — Cincinnati VA Medical Center Research
- Study coordinator: Madan, Rajat
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.