Understanding how different types of immune cells affect C. difficile infections
Impact of neutrophil heterogeneity on pathogenesis of C. difficile infection
['FUNDING_OTHER'] · CINCINNATI VA MEDICAL CENTER RESEARCH · NIH-10917739
This study is looking at how a type of immune cell called neutrophils affects people with Clostridium difficile infections, aiming to find out what helps or harms recovery, so we can create better treatments that focus on the body's immune response.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI VA MEDICAL CENTER RESEARCH (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10917739 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the outcomes of Clostridium difficile infections (CDI). The team aims to identify both harmful and helpful host factors that influence disease progression, focusing on how neutrophils contribute to inflammation and intestinal damage during CDI. By using advanced techniques like single cell transcriptomics, they are mapping the behavior of neutrophils in the blood and intestines of patients with CDI. The ultimate goal is to develop new therapies that target the host's immune response rather than just the bacteria itself.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Clostridium difficile infections.
Not a fit: Patients who do not have C. difficile infections or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve recovery and outcomes for patients suffering from C. difficile infections.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in infections, suggesting that this approach could yield significant insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI VA MEDICAL CENTER RESEARCH — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADAN, RAJAT — CINCINNATI VA MEDICAL CENTER RESEARCH
- Study coordinator: MADAN, RAJAT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.