Understanding how different types of eosinophil cell death affect health
Official title: Pathophysiological impact of subtypes of eosinophil cell death
Funded at University of Cincinnati · NIH-10825101 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called eosinophils affects conditions like asthma and heart disease, to help us understand how they can sometimes help our bodies and other times cause problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $46,386 |
| NIH project number | 1F31HL172649-01 |
| Project ID | NIH-10825101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from eosinophilic-associated diseases, particularly those with asthma or eosinophilic heart disease.
✕Less likely to help
Patients with conditions unrelated to eosinophilic diseases or those who do not have elevated eosinophil levels may not benefit from this research.
What this research studies
This research investigates the role of eosinophils, a type of white blood cell, in various immune diseases, particularly focusing on their involvement in conditions like asthma and eosinophilic heart disease. The study aims to understand how different mechanisms of eosinophil cell death, including a process called cytolysis, influence tissue health and disease progression. By using mouse models, researchers will explore how the release of eosinophil contents affects heart cells and overall immune responses. This could provide insights into how eosinophils can be both protective and harmful in different contexts.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions associated with eosinophils, improving patient outcomes in diseases like asthma and eosinophilic heart disease.
How similar studies have gone: Previous research has shown that understanding the mechanisms of cell death in immune cells can lead to significant advancements in treatment strategies, indicating potential success for this approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Osuji, Immaculeta Kasarachi — University of Cincinnati
- Study coordinator: Osuji, Immaculeta Kasarachi
Related research
Other NIH-funded projects on the same topics.
-
Immune and nerve signals behind acupuncture relief for sickle cell pain
This NIH grant explores how acupuncture helps reduce pain and opioid use for people with sickle cell disease.
-
MnSOD modification drives a stem-cell like switch in some ER-positive breast cancers
A small study in ER-positive breast cancer looks at how a specific mitochondrial change (MnSOD-K68 acetylation) may push cancer cells toward a more stem-like, therapy-resistant state.
-
Lineage changes in cancer cells drive resistance to radiation and hormone therapy
A cancer-focused study looks at how a mitochondrial enzyme modification may cause tumor cells to resist radiation and hormone therapy in prostate cancer.
-
Repurposed Antiretroviral Therapies to Eliminate Cervical Cancer
A pilot study tests a self-administered vaginal capsule with protease inhibitors to safely treat cervical precancer (CIN 2/3) in women, using a non-invasive approach.
-
Recombinant factor VIIa given very early for bleeding stroke
This trial gives a clotting medicine called rFVIIa very soon after a spontaneous brain bleed to adults to try to improve recovery.
-
Early Factor VIIa treatment for bleeding stroke
This project tests whether giving a clotting medicine called recombinant Factor VIIa very soon after a spontaneous brain bleed helps adults recover better than standard care alone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.