Understanding how different types of endometriosis-related ovarian cancers affect survival and treatment response
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
This study is looking at different types of ovarian cancer linked to endometriosis to find out how their unique features affect treatment and survival, with the goal of helping doctors create more personalized treatment plans for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11011444 on NIH RePORTER |
What this research studies
This research investigates the molecular subtypes of endometriosis-associated ovarian cancers, specifically endometrioid and clear cell types, to understand their unique biological characteristics and how these relate to patient survival and treatment outcomes. By analyzing genomic data from approximately 1,100 tumors, the study aims to identify specific risk factors and molecular profiles that could lead to more effective, personalized treatment strategies. The approach includes examining how factors like smoking and body mass index influence cancer progression and response to chemotherapy. This research seeks to bridge the gap in precision therapy for these challenging cancer types.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometrioid or clear cell ovarian cancers, particularly those with a history of endometriosis.
Not a fit: Patients with other types of ovarian cancer or those without a history of endometriosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and survival rates for patients with endometriosis-associated ovarian cancers.
How similar studies have performed: Previous research has shown promise in identifying molecular subtypes in other cancer types, suggesting that this approach could yield valuable insights for endometriosis-associated ovarian cancers as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Goode, Ellen L. — Mayo Clinic Rochester
- Study coordinator: Goode, Ellen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.