Understanding how different types of collagen affect heart scar healing
Role of collagen heterogeneity in remodeling of acute and chronic heart scars
This study is looking at how different types of collagen help the heart heal after an injury, like a heart attack, to find out how they affect scar tissue, which could lead to better treatments and recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10642804 on NIH RePORTER |
What this research studies
This research investigates the role of various collagens in the healing process of the heart after injury, particularly focusing on how these proteins influence the formation and size of scar tissue. By mapping collagen types in the heart and using advanced genetic techniques, the study aims to uncover the mechanisms that regulate scar tissue development following heart attacks. Patients may benefit from insights that could lead to improved treatments for heart damage and better recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an acute myocardial infarction and are dealing with heart scar formation.
Not a fit: Patients who have not experienced heart injury or those with non-cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart healing and improve survival rates after heart attacks.
How similar studies have performed: Previous research has shown that understanding the extracellular matrix can significantly impact treatment strategies for heart conditions, indicating a promising avenue for this study.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Deb, Arjun — University of California Los Angeles
- Study coordinator: Deb, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.