Understanding how different tissues heal after injury
Spatio-temporal cellular dynamics regulating differential healing outcomes
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10939049
This study is looking at how different types of wounds heal, especially why mouth wounds seem to heal faster than skin wounds, to find ways to help everyone heal better, whether they have a regular injury or a more serious condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10939049 on ClinicalTrials.gov |
What this research studies
This research investigates the healing processes of various tissues, particularly focusing on how wounds in the oral cavity heal faster than those on the skin. By examining the cellular dynamics involved in the healing phases—Inflammatory, Proliferative, and Resolution—the study aims to identify critical points where healing can be optimized or becomes pathological. Utilizing advanced single-cell and spatial sequencing technologies, the research will compare healthy healing with chronic and cancerous conditions to uncover insights that could improve healing outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic wounds, such as those with diabetes, or patients experiencing abnormal healing processes.
Not a fit: Patients with acute injuries that heal normally without complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic wounds and better healing strategies for various injuries.
How similar studies have performed: While there has been research on healing processes, this study's specific focus on comparing oral and skin healing at the single-cell level is relatively novel.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIETECHA, MATEUSZ S — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: WIETECHA, MATEUSZ S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Induction, Cancers