Understanding how different structures of mRNA delivery systems affect their function.
Structure-Property-Function Relationship in mRNA/CARTs for Targeted mRNA Delivery
['FUNDING_FELLOWSHIP'] · STANFORD UNIVERSITY · NIH-11015771
This study is exploring new ways to help deliver mRNA treatments more effectively to specific organs, which could lead to better therapies for diseases like cancer.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11015771 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the delivery of mRNA therapies using charge-altering releasable transporter (CART) vectors. By studying how variations in the chemical structure of these vectors influence their ability to deliver mRNA effectively and safely to specific organs, the research aims to create optimized formulations for targeted therapies. The project employs advanced imaging techniques and microfluidic mixing protocols to analyze the properties and behaviors of these delivery systems in cell cultures. If successful, this work could lead to more effective mRNA-based treatments for various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who may benefit from mRNA therapies, particularly those with cancer or viral infections.
Not a fit: Patients who do not require mRNA-based treatments or those with conditions unrelated to the targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted mRNA therapies for patients.
How similar studies have performed: Previous research has shown promise in using similar approaches for targeted mRNA delivery, indicating potential for success in this area.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HURST, PAUL JOSHUA — STANFORD UNIVERSITY
- Study coordinator: HURST, PAUL JOSHUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer therapy, Cancer Treatment, cancer-directed therapy