Understanding how different strains of skin bacteria affect health and infections
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
This study is looking at different types of a common skin bacteria called Staphylococcus epidermidis to see how they can affect our skin health and cause infections, especially for people with medical devices, and it aims to find new ways to prevent and treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11229871 on NIH RePORTER |
What this research studies
This research investigates the diverse strains of Staphylococcus epidermidis, a common bacterium found on human skin, to understand how they contribute to both health and disease. By examining the genetic differences among these strains, the study aims to uncover how they interact with the immune system and influence skin health. The researchers will use advanced techniques, including CRISPR technology, to manipulate specific genes in these bacteria and observe the effects on their behavior and ability to cause infections. This work could lead to new insights into preventing and treating infections related to medical devices and bloodstream issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with skin infections or those who have had medical devices implanted.
Not a fit: Patients who do not have any skin infections or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating infections caused by Staphylococcus epidermidis.
How similar studies have performed: Other research has shown promising results in understanding bacterial diversity and its implications for health, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Oh, Julia — Duke University
- Study coordinator: Oh, Julia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.