Understanding how different strains of Akkermansia muciniphila grow and respond to human milk and bile.
Official title: Mechanisms and consequences of human milk oligosaccharide growth and bile stress across diverse strains of the potential therapeutic bacterium, Akkermansia muciniphila.
Funded at California State University Northridge · NIH-10672449 · Data updated 2026-11-12
This study is looking at different types of a helpful gut bacteria called Akkermansia muciniphila to see how they grow with certain sugars found in human milk and how they handle bile, with the goal of finding new ways to improve gut health that could help people like you through better probiotics or diet tips.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | July 9, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $362,500 |
| NIH project number | 5SC1GM136546-04 |
| Project ID | NIH-10672449 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal disorders or metabolic conditions who may benefit from enhanced gut microbiome health.
✕Less likely to help
Patients who do not have gastrointestinal issues or metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the diverse strains of the beneficial gut bacterium Akkermansia muciniphila, focusing on how they grow on human milk oligosaccharides and respond to bile stress. By examining the molecular mechanisms and immunogenic properties of these strains, the research aims to develop targeted therapies that could enhance gut health. Patients may benefit from insights that could lead to new probiotic treatments or dietary recommendations to improve metabolic and gastrointestinal health.
Why it matters
Potential benefit: If successful, this research could lead to improved probiotic therapies that enhance gut health and manage metabolic disorders.
How similar studies have gone: Previous research has shown promising results with Akkermansia muciniphila in gut health, but this specific approach to studying diverse strains is relatively novel.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Flores, Gilberto — California State University Northridge
- Study coordinator: Flores, Gilberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.