Understanding how different psychosocial treatments for chronic pain work

Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments

['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-10866560

This study is looking at how different types of therapy can help people with long-lasting pain in their muscles and joints, and it wants to find out what makes these treatments work better for some people than others, so that everyone can get the best care possible.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorRUSH UNIVERSITY MEDICAL CENTER (nih funded)
Locations1 site (CHICAGO, UNITED STATES)
Trial IDNIH-10866560 on ClinicalTrials.gov

What this research studies

This research investigates the effectiveness of various psychosocial treatments for chronic musculoskeletal pain by examining the mechanisms that contribute to their success. It aims to identify specific factors that enhance treatment outcomes and to understand which patient characteristics influence responses to these treatments. By comparing different interventions, the study seeks to uncover shared and unique mediators of treatment effects, ultimately aiming to improve existing therapies. The findings could lead to more personalized treatment approaches for individuals suffering from chronic pain.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who experience chronic musculoskeletal pain.

Not a fit: Patients with acute pain conditions or those under 21 years old may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective and tailored treatments for individuals with chronic pain.

How similar studies have performed: Previous research has shown promise in understanding treatment mechanisms for chronic pain, but this approach aims to deepen that understanding in a comparative context.

Where this research is happening

CHICAGO, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.