Understanding how different primate species respond to tuberculosis infection
Immunogenomics of susceptibility to tuberculosis (TB) among nonhuman primate species
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10873806
This study is looking at how genetics might make different types of monkeys more or less likely to get tuberculosis (TB), so researchers can learn more about the immune responses and find better treatments for people with TB.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10873806 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that influence susceptibility to tuberculosis (TB) among various nonhuman primate species. By comparing the immune responses of different primates, such as rhesus and cynomolgus macaques, the study aims to identify specific genes that may affect how these species respond to TB infection. Researchers will use advanced techniques like long-read RNA sequencing to analyze blood cells from these primates after exposure to TB bacteria. The goal is to uncover the underlying mechanisms that contribute to differences in TB susceptibility, which could inform future treatments for humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with a known susceptibility to tuberculosis or those who have been exposed to TB.
Not a fit: Patients who are not at risk for tuberculosis or do not have a history of exposure to the disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of TB susceptibility, potentially guiding the development of targeted therapies for humans.
How similar studies have performed: Previous research has shown success in using comparative genomics to understand disease susceptibility in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROODGAR, MORTEZA — STANFORD UNIVERSITY
- Study coordinator: ROODGAR, MORTEZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.