Understanding how different primate species respond to tuberculosis infection
Official title: Immunogenomics of susceptibility to tuberculosis (TB) among nonhuman primate species
Funded at Stanford University · NIH-10873806 · Data updated 2026-11-12
This study is looking at how genetics might make different types of monkeys more or less likely to get tuberculosis (TB), so researchers can learn more about the immune responses and find better treatments for people with TB.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $117,810 |
| NIH project number | 5K01OD030516-03 |
| Project ID | NIH-10873806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with a known susceptibility to tuberculosis or those who have been exposed to TB.
✕Less likely to help
Patients who are not at risk for tuberculosis or do not have a history of exposure to the disease may not receive any benefit from this research.
What this research studies
This research investigates the genetic factors that influence susceptibility to tuberculosis (TB) among various nonhuman primate species. By comparing the immune responses of different primates, such as rhesus and cynomolgus macaques, the study aims to identify specific genes that may affect how these species respond to TB infection. Researchers will use advanced techniques like long-read RNA sequencing to analyze blood cells from these primates after exposure to TB bacteria. The goal is to uncover the underlying mechanisms that contribute to differences in TB susceptibility, which could inform future treatments for humans.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of TB susceptibility, potentially guiding the development of targeted therapies for humans.
How similar studies have gone: Previous research has shown success in using comparative genomics to understand disease susceptibility in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Roodgar, Morteza — Stanford University
- Study coordinator: Roodgar, Morteza
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.