Understanding how different people respond to influenza infections
Deciphering the Heterogeneous Response to Influenza by a Multi-Scale Systems Approach
This study is looking at how kids and other high-risk groups respond to the flu virus to understand why some people get better faster than others, and it invites participants to share their health info and samples to help improve flu vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10873103 on NIH RePORTER |
What this research studies
This research investigates the varied immune responses to influenza viruses, particularly in young children and other high-risk groups. By analyzing how antibodies and immune cells interact with different strains of the virus, the study aims to uncover why some individuals recover better than others. The approach involves advanced techniques to assess immune responses and the effectiveness of existing vaccines against circulating strains. Patients may contribute by providing samples and health information to help clarify these immune mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation include children under 11 years old, especially those with compromised immune systems or other risk factors.
Not a fit: Patients who are not within the targeted age group or do not have any risk factors for severe influenza may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for influenza, particularly for vulnerable populations.
How similar studies have performed: Previous research has shown promise in understanding immune responses to influenza, but this multi-scale systems approach is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Forst, Christian — Icahn School of Medicine at Mount Sinai
- Study coordinator: Forst, Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.