Understanding how different organs communicate in allergic diseases
Cellular and molecular mechanisms of mucosal organ crosstalk in allergic diseases
This study is looking at how allergies, like food allergies and asthma, can affect each other in the body, using mice to learn more about how allergens impact both the gut and lungs, with the hope of finding better treatments for people dealing with multiple allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11078796 on NIH RePORTER |
What this research studies
This research investigates the interactions between mucosal organs in individuals with allergic diseases, such as food allergies and asthma. By using mouse models, the study examines how allergens can trigger immune responses not only in the gut but also in the lungs, potentially leading to worsened allergic reactions. The researchers aim to uncover the cellular and molecular mechanisms behind this crosstalk, which could help identify new treatment strategies for patients suffering from multiple allergic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from food allergies, allergic asthma, or other allergic diseases.
Not a fit: Patients without any form of allergic disease or those with non-allergic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with allergic diseases by targeting the underlying mechanisms of organ crosstalk.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in allergic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Spencer, Lisa Ann — University of Colorado Denver
- Study coordinator: Spencer, Lisa Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.