Understanding how different macrophages support lung development.
Diverse Homeostatic Roles for Distinct Macrophages in the Developing Lung Vasculature
This study is looking at how different types of immune cells called macrophages help form blood vessels in the lungs as they grow after birth, which could help us understand lung development problems better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11222411 on NIH RePORTER |
What this research studies
This research investigates the roles of various types of macrophages in the development of lung blood vessels, particularly during the critical postnatal period when the lungs are maturing. By using advanced techniques like single cell RNA-sequencing, the study aims to identify the diversity of macrophages and their specific functions in promoting blood vessel formation and lung growth. The findings could provide insights into how disruptions in these processes might lead to lung development issues.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit would include infants or children with lung development issues or related vascular abnormalities.
Not a fit: Patients with fully developed lungs or those not experiencing any lung-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating lung development disorders in infants.
How similar studies have performed: While the specific role of macrophages in lung development is not well-studied, similar approaches in other organs have shown promising results in understanding vascular development.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Alvira, Cristina Maria — University of California, San Francisco
- Study coordinator: Alvira, Cristina Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.