Understanding how different levels of transcription factors affect facial development and related diseases
Official title: Mapping and prediction of quantitative transcription factor dosage effects to understand variation in craniofacial morphology and disease
Funded at Boston Children's Hospital · NIH-11140681 · Data updated 2026-11-12
This study is looking at how different levels of certain proteins that control gene activity affect the way our faces develop, which could help us understand facial differences and disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00DE032729-03 |
| Project ID | NIH-11140681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with craniofacial abnormalities or genetic syndromes affecting facial morphology.
✕Less likely to help
Patients without craniofacial abnormalities or those not affected by related genetic conditions may not benefit from this research.
What this research studies
This research investigates how varying amounts of transcription factors, which are proteins that help regulate gene expression, influence the development of the human face and associated disorders. By focusing on cranial neural crest cells, which are crucial for facial formation, the study aims to identify the specific genetic elements that respond to changes in transcription factor levels. The research will utilize advanced techniques to manipulate these factors and assess their effects on molecular, cellular, and physical traits. Ultimately, this work seeks to provide insights into the genetic basis of craniofacial variations and disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial abnormalities and related genetic disorders.
How similar studies have gone: Other research has shown promising results in understanding transcription factor roles in development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Naqvi, Sahin — Boston Children's Hospital
- Study coordinator: Naqvi, Sahin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.