Understanding how different KRAS mutations affect lung cancer
Genetic dissection of oncogenic Kras signaling
This study is looking at how different changes in the KRAS gene, which is often linked to lung cancer, affect the disease and treatment, using mice to help find better therapies that could work for patients with specific KRAS mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10881785 on NIH RePORTER |
What this research studies
This research investigates the role of various mutations in the KRAS gene, which is commonly associated with lung cancer. By using advanced techniques like CRISPR/Cas9, the researchers aim to create and analyze different KRAS variants in mouse models to understand their unique effects on cancer development. The study combines genetic engineering with quantitative genomics to explore how these mutations influence cancer signaling pathways and treatment responses. Patients may benefit from insights that could lead to more effective therapies tailored to their specific KRAS mutation.
Who could benefit from this research
Good fit: Ideal candidates for this research are lung cancer patients with identified KRAS mutations.
Not a fit: Patients without KRAS mutations or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment options for lung cancer patients with specific KRAS mutations.
How similar studies have performed: Other research has shown promising results using CRISPR technology to study cancer genetics, indicating potential for success in this approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Winslow, Monte Meier — Stanford University
- Study coordinator: Winslow, Monte Meier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.