Understanding how different HIV types affect disease progression in children
Virologic and Immunologic Correlates of Disease Progression in Perinatal HIV
This study looks at how different types of HIV affect how children's immune systems respond and how quickly their health changes, helping us understand why some kids with HIV get sick faster or slower than others.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10997409 on NIH RePORTER |
What this research studies
This research investigates how various HIV subtypes influence the immune response and clinical outcomes in children born with HIV. By studying children with perinatal HIV, the research aims to identify factors that contribute to faster disease progression or, conversely, to slower progression in some children. The study will analyze viral replication capacity and its correlation with immune markers and disease indicators. This could provide valuable insights into pediatric HIV management and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with perinatal HIV, particularly those living in sub-Saharan Africa.
Not a fit: Patients who are not affected by perinatal HIV or those who are adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment approaches for children living with HIV, potentially enhancing their health outcomes.
How similar studies have performed: Previous research has shown that understanding viral subtypes and their impact on disease progression in adults can lead to significant advancements in treatment, suggesting potential success in this area for children as well.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Khaitan, Alka — Indiana University Indianapolis
- Study coordinator: Khaitan, Alka
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.