Understanding how different HIV types affect disease progression in children
Official title: Virologic and Immunologic Correlates of Disease Progression in Perinatal HIV
Funded at Indiana University Indianapolis · NIH-10997409 · Data updated 2026-11-12
This study looks at how different types of HIV affect how children's immune systems respond and how quickly their health changes, helping us understand why some kids with HIV get sick faster or slower than others.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 8, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $174,137 |
| NIH project number | 5R21HD114230-02 |
| Project ID | NIH-10997409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with perinatal HIV, particularly those living in sub-Saharan Africa.
✕Less likely to help
Patients who are not affected by perinatal HIV or those who are adults may not benefit from this research.
What this research studies
This research investigates how various HIV subtypes influence the immune response and clinical outcomes in children born with HIV. By studying children with perinatal HIV, the research aims to identify factors that contribute to faster disease progression or, conversely, to slower progression in some children. The study will analyze viral replication capacity and its correlation with immune markers and disease indicators. This could provide valuable insights into pediatric HIV management and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment approaches for children living with HIV, potentially enhancing their health outcomes.
How similar studies have gone: Previous research has shown that understanding viral subtypes and their impact on disease progression in adults can lead to significant advancements in treatment, suggesting potential success in this area for children as well.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Khaitan, Alka — Indiana University Indianapolis
- Study coordinator: Khaitan, Alka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.