Understanding how different heart cell types affect heart function
Official title: Mechanistic modeling to link scRNAseq data to physiological predictions
Funded at Icahn School of Medicine at Mount Sinai · NIH-10905742 · Data updated 2026-11-12
This study is looking at different types of heart cells to see how they work together and affect heart function, which could help us understand heart diseases better and find new treatments for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $252,854 |
| NIH project number | 1R21HL174051-01 |
| Project ID | NIH-10905742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac conditions or those interested in the cellular mechanisms of heart function.
✕Less likely to help
Patients with non-cardiac conditions or those who do not have any heart-related issues may not benefit from this research.
What this research studies
This research aims to explore how various subtypes of heart muscle cells, known as cardiomyocytes, influence the overall function of the heart. By utilizing advanced techniques like single-cell RNA sequencing (scRNAseq), the researchers will identify these cell subtypes and their gene expression patterns. They will then create mathematical models to predict how these differences affect heart activity, which will be validated through physiological experiments measuring heart cell behavior. This approach could lead to new insights into heart diseases and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for heart diseases by identifying how different heart cell types contribute to cardiac function.
How similar studies have gone: Other research has shown promise in linking gene expression data to physiological outcomes, suggesting that this approach could yield significant insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Sobie, Eric a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sobie, Eric a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.