Understanding how different heart cell types affect heart function
Mechanistic modeling to link scRNAseq data to physiological predictions
['FUNDING_R21'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10905742
This study is looking at different types of heart cells to see how they work together and affect heart function, which could help us understand heart diseases better and find new treatments for them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10905742 on ClinicalTrials.gov |
What this research studies
This research aims to explore how various subtypes of heart muscle cells, known as cardiomyocytes, influence the overall function of the heart. By utilizing advanced techniques like single-cell RNA sequencing (scRNAseq), the researchers will identify these cell subtypes and their gene expression patterns. They will then create mathematical models to predict how these differences affect heart activity, which will be validated through physiological experiments measuring heart cell behavior. This approach could lead to new insights into heart diseases and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac conditions or those interested in the cellular mechanisms of heart function.
Not a fit: Patients with non-cardiac conditions or those who do not have any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for heart diseases by identifying how different heart cell types contribute to cardiac function.
How similar studies have performed: Other research has shown promise in linking gene expression data to physiological outcomes, suggesting that this approach could yield significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOBIE, ERIC A — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SOBIE, ERIC A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases, Cardiac Diseases, Cardiac Disorders