Understanding how different forms of transcription factors affect gene regulation
Official title: Functional genomics approaches to decode the roles of transcription factor isoforms
Funded at Brigham and Women's Hospital · NIH-11017712 · Data updated 2026-11-12
This study is looking at different versions of proteins that help control how our genes work, especially in cancer, to better understand how they might affect cell growth and behavior.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $127,170 |
| NIH project number | 5K99HG013345-02 |
| Project ID | NIH-11017712 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer or other cancers where transcription factor misregulation is suspected.
✕Less likely to help
Patients with conditions unrelated to transcription factor regulation or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research aims to explore the various roles of transcription factor isoforms, which are proteins that regulate gene expression and are crucial for cell growth and differentiation. By using advanced functional genomics techniques, the study will systematically characterize how these isoforms function within cells, particularly in the context of cancer. The research will involve high-throughput screening methods to analyze the interactions and effects of over 700 different transcription factor isoforms, providing insights into their contributions to gene regulatory networks. This could lead to a better understanding of how misregulation of these factors may contribute to diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and potentially identify novel therapeutic targets for treatment.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through functional genomics, indicating that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Mattioli, Kaia — Brigham and Women's Hospital
- Study coordinator: Mattioli, Kaia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.