Understanding how different forms of transcription factors affect gene regulation
Functional genomics approaches to decode the roles of transcription factor isoforms
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11017712
This study is looking at different versions of proteins that help control how our genes work, especially in cancer, to better understand how they might affect cell growth and behavior.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11017712 on ClinicalTrials.gov |
What this research studies
This research aims to explore the various roles of transcription factor isoforms, which are proteins that regulate gene expression and are crucial for cell growth and differentiation. By using advanced functional genomics techniques, the study will systematically characterize how these isoforms function within cells, particularly in the context of cancer. The research will involve high-throughput screening methods to analyze the interactions and effects of over 700 different transcription factor isoforms, providing insights into their contributions to gene regulatory networks. This could lead to a better understanding of how misregulation of these factors may contribute to diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer or other cancers where transcription factor misregulation is suspected.
Not a fit: Patients with conditions unrelated to transcription factor regulation or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and potentially identify novel therapeutic targets for treatment.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through functional genomics, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATTIOLI, KAIA — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: MATTIOLI, KAIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.