Understanding how different forms of the WT1 protein interact with other proteins
Identification of isoform-specific WT1 interaction partners
This study is looking at a protein called WT1, which is important for how our kidneys work, to understand how different versions of it interact with other proteins in the body and how changes in this protein might affect health and disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11036545 on NIH RePORTER |
What this research studies
This research investigates the WT1 protein, which is crucial for kidney development and function, and its various forms that may behave differently in the body. The study will use advanced techniques to identify specific proteins that interact with these different WT1 isoforms, helping to uncover their unique roles in health and disease. By focusing on the mechanisms that regulate WT1 activity and how mutations affect its function, the research aims to fill important gaps in our understanding of this protein's biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Wilms tumors, progressive glomerulopathy, or related disorders linked to WT1 mutations.
Not a fit: Patients without any known WT1-related conditions or those who are not affected by kidney or related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of conditions like Wilms tumors and other disorders related to WT1 dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the roles of protein isoforms in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mann, Nina — Boston Children's Hospital
- Study coordinator: Mann, Nina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.