Understanding how different forms of the WT1 protein interact with other proteins
Official title: Identification of isoform-specific WT1 interaction partners
Funded at Boston Children's Hospital · NIH-11036545 · Data updated 2026-11-12
This study is looking at a protein called WT1, which is important for how our kidneys work, to understand how different versions of it interact with other proteins in the body and how changes in this protein might affect health and disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $133,500 |
| NIH project number | 1R03DK142029-01 |
| Project ID | NIH-11036545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Wilms tumors, progressive glomerulopathy, or related disorders linked to WT1 mutations.
✕Less likely to help
Patients without any known WT1-related conditions or those who are not affected by kidney or related cancers may not benefit from this research.
What this research studies
This research investigates the WT1 protein, which is crucial for kidney development and function, and its various forms that may behave differently in the body. The study will use advanced techniques to identify specific proteins that interact with these different WT1 isoforms, helping to uncover their unique roles in health and disease. By focusing on the mechanisms that regulate WT1 activity and how mutations affect its function, the research aims to fill important gaps in our understanding of this protein's biology.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of conditions like Wilms tumors and other disorders related to WT1 dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the roles of protein isoforms in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Mann, Nina — Boston Children's Hospital
- Study coordinator: Mann, Nina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.