Understanding how different forms of the TOX protein affect T cell development
Official title: Characterization of TOX isoform-specific roles in T cell and ILC development
Funded at Cedars-Sinai Medical Center · NIH-11039500 · Data updated 2026-11-12
This study is looking at how different versions of a protein called TOX affect the growth of important immune cells, which could help us understand better how our immune system works and find new ways to treat conditions like autoimmune diseases and cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | February 24, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $202,488 |
| NIH project number | 1R21AI188177-01 |
| Project ID | NIH-11039500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune conditions or cancers that involve T cell dysfunction.
✕Less likely to help
Patients with non-immune related conditions or those not affected by T cell-related issues may not benefit from this research.
What this research studies
This research investigates the roles of different isoforms of the TOX protein in the development of T cells and innate lymphoid cells (ILCs). By examining how these isoforms are produced and how they influence gene expression, the study aims to uncover new insights into immune system functioning. The researchers will utilize advanced techniques to analyze the effects of these protein variations on T cell lineage development and their implications in conditions like autoimmunity and cancer. This work could lead to a better understanding of immune responses and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and cancers by targeting specific protein functions in T cells.
How similar studies have gone: Previous research has shown promising results in understanding the roles of protein isoforms in immune function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Kaye, Jonathan G — Cedars-Sinai Medical Center
- Study coordinator: Kaye, Jonathan G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.