Understanding how different forms of a protein affect brain function in Alzheimer's disease
Project 1: Differential Roles of ApoE Isoforms in Neural Network Dysfunction of Alzheimer's Disease
This study is looking at how different forms of a protein called apoE, especially the APOE4 version, affect brain function and memory problems in people with Alzheimer's disease, with the goal of finding new ways to help improve treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897921 on NIH RePORTER |
What this research studies
This research investigates the roles of different isoforms of apolipoprotein E (apoE) in the dysfunction of neural networks associated with Alzheimer's disease (AD). It aims to explore how these isoforms, particularly the APOE4 variant, contribute to cognitive decline and the onset of AD. By examining the interactions between amyloid-beta peptides, tau proteins, and apoE, the study seeks to identify new therapeutic targets that could improve treatment outcomes for patients. The approach involves analyzing brain function and pathology in relation to genetic factors, providing insights into the complex mechanisms underlying AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who are APOE4 carriers.
Not a fit: Patients without any genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease, particularly for those at genetic risk.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in Alzheimer's disease, but this specific approach focusing on neural network dysfunction is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Huang, Yadong — J. David Gladstone Institutes
- Study coordinator: Huang, Yadong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.