Understanding how different forms of a gene affect Alzheimer's disease progression
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11013902
This study is looking at how different versions of a gene called APOE might affect the way Alzheimer's disease develops, using mice to see how these gene differences impact brain function and energy use, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11013902 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of different apolipoprotein E (APOE) gene forms on the development of Alzheimer's disease. Using a specially created mouse model, the study will explore how these gene variations influence brain processes, including neuronal activity and energy regulation. Through a combination of behavioral tests and advanced imaging techniques, researchers aim to map out the timing and location of these effects in the brain across different ages. The findings could provide insights into the mechanisms behind Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those who are carriers of the APOE ε4 gene.
Not a fit: Patients without any genetic predisposition to Alzheimer's disease or those who do not have a family history of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Alzheimer's disease, particularly for those at higher genetic risk.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE in Alzheimer's disease, indicating that this approach is building on established findings.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NURIEL, TAL — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: NURIEL, TAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia