Understanding how different factors cause insulin resistance in the body.
The cellular molecular regulation of differing mechanisms of insulin resistance.
['FUNDING_R01'] · HOWARD UNIVERSITY · NIH-10892042
This study is looking at how certain diets and hormones affect the liver and cause insulin resistance, using mice to understand how things like high fat and high sugar diets, along with hormone levels, play a role, which could help find better treatments for people with insulin resistance.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HOWARD UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10892042 on ClinicalTrials.gov |
What this research studies
This research investigates the various mechanisms that lead to insulin resistance, particularly focusing on how different diets and hormonal factors affect liver function. By using mouse models, the study aims to explore how high androgen levels, high fat diets, and high fructose diets contribute to insulin resistance through distinct cellular and molecular pathways. The researchers will utilize specific genetic modifications in these models to pinpoint the interactions between these mechanisms. This approach may help identify targeted treatments for insulin resistance in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing insulin resistance or related metabolic conditions.
Not a fit: Patients who are not experiencing insulin resistance or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating insulin resistance and related metabolic disorders in patients.
How similar studies have performed: Previous research has shown promising results in understanding insulin resistance mechanisms, but this specific approach using multiple dietary and hormonal factors is relatively novel.
Where this research is happening
WASHINGTON, UNITED STATES
- HOWARD UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDRISSE, STANLEY — HOWARD UNIVERSITY
- Study coordinator: ANDRISSE, STANLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus