Understanding how different factors affect treatment responses in Alzheimer's patients
Official title: Leveraging 30 years of Alzheimer's disease clinical trials data to decipher phenotypic response to treatment
Funded at University of California, San Diego · NIH-10950572 · Data updated 2026-11-12
This study is looking at how things like gender and genetics can affect how well different treatments work for people with Alzheimer's, so we can find better ways to help each person based on their unique needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $3,281,385 |
| NIH project number | 1RF1AG088811-01 |
| Project ID | NIH-10950572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those with varying APOE4 statuses and different demographic characteristics.
✕Less likely to help
Patients with early-stage Alzheimer's or those without identifiable phenotypic characteristics may not benefit from this research.
What this research studies
This research investigates how specific characteristics, such as gender, genetic factors like APOE4 status, and baseline biomarker levels, influence the effectiveness of drug and lifestyle interventions in Alzheimer's disease. By analyzing data from 30 years of clinical trials, the study aims to identify distinct subgroups of patients who may respond differently to treatments. This precision medicine approach seeks to enhance our understanding of Alzheimer's risk and pathology, ultimately leading to more tailored and effective treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for Alzheimer's patients, improving their quality of life and treatment outcomes.
How similar studies have gone: Previous research has shown promising results in understanding treatment responses based on genetic and demographic factors, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: PA, Judy — University of California, San Diego
- Study coordinator: PA, Judy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.