Understanding how different cells respond to viral infections
Harnessing cell-to-cell variability to understand viral infection outcomes
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10888298
This study looks at how different cells react to the Herpes Simplex Virus 1, trying to find out why some cells fight off the virus while others end up making a lot more of it; the goal is to learn more about these reactions to help create better treatments for viral infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10888298 on ClinicalTrials.gov |
What this research studies
This research investigates how individual cells respond differently to viral infections, specifically focusing on Herpes Simplex Virus 1 (HSV-1). By examining the variability in infection outcomes at the single-cell level, the study aims to identify factors that determine whether a cell aborts the infection or becomes a 'super producer' that releases many viral progeny. The research employs advanced technologies to analyze virus-host interactions and seeks to uncover the molecular mechanisms behind these diverse responses. This knowledge could lead to the development of new antiviral therapies and improve our understanding of viral behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with Herpes Simplex Virus 1 (HSV-1) who are experiencing varied responses to the infection.
Not a fit: Patients with viral infections other than HSV-1 may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new antiviral strategies that enhance treatment outcomes for patients with viral infections.
How similar studies have performed: Previous research has shown promise in understanding viral infections at the single-cell level, suggesting that this approach could yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRAYMAN, NIR — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: DRAYMAN, NIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.