Understanding how different cells in skin cancer tumors interact and affect growth
Cancer Cell-Extrinsic and Intrinsic Regulators of Tumorigenesis
This study is looking at how different types of cells in and around cutaneous squamous cell carcinoma (a common skin cancer) affect how the tumor grows and behaves, with the goal of finding new treatment options for patients, especially those whose tumors can't be surgically removed.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10915507 on NIH RePORTER |
What this research studies
This research investigates cutaneous squamous cell carcinoma (cSCC), a common skin cancer, focusing on how various cell types within the tumor and surrounding environment influence tumor behavior and growth. By utilizing advanced techniques like single-cell profiling, the study aims to identify specific tumor cell subpopulations and their interactions with immune and stromal cells. This approach seeks to uncover the mechanisms behind tumor heterogeneity and communication, which could lead to new treatment strategies for patients with cSCC, especially those with unresectable cases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cutaneous squamous cell carcinoma, particularly those with advanced or unresectable tumors.
Not a fit: Patients with early-stage cSCC that can be surgically removed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatment options for patients with advanced skin cancer, improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments and their impact on cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ji, Andrew — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ji, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.