Understanding how different cell types use genes in single cells
Differential exon usage in single cell RNA-seq
['FUNDING_OTHER'] · UNIVERSITY OF NEVADA LAS VEGAS · NIH-11089334
This study is looking at how different ways genes can be spliced affect how cells work, using a special technique to look at individual cells, and it aims to create better methods for understanding how cells grow and change, which could help us learn more about diseases and development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEVADA LAS VEGAS (nih funded) |
| Locations | 1 site (LAS VEGAS, UNITED STATES) |
| Trial ID | NIH-11089334 on ClinicalTrials.gov |
What this research studies
This research investigates how alternative splicing affects gene expression in different cell types using single cell RNA sequencing (scRNA-seq). It aims to develop a new method to accurately identify splicing events that are often overlooked due to technical challenges in current scRNA-seq analysis. By comparing existing techniques and evaluating new protocols, the research seeks to enhance the understanding of how cells differentiate and develop. This could lead to improved analysis pipelines for studying various diseases and developmental processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve cellular differentiation or developmental disorders.
Not a fit: Patients with conditions unrelated to cellular differentiation or splicing abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into cellular differentiation and organ development, potentially leading to better diagnostic and therapeutic strategies for diseases related to splicing abnormalities.
How similar studies have performed: Other research has shown promise in improving scRNA-seq analysis techniques, but this specific approach to alternative splicing in single cells is relatively novel.
Where this research is happening
LAS VEGAS, UNITED STATES
- UNIVERSITY OF NEVADA LAS VEGAS — LAS VEGAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAN, MIRA — UNIVERSITY OF NEVADA LAS VEGAS
- Study coordinator: HAN, MIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.