Understanding how different cell types use genes in single cells
Official title: Differential exon usage in single cell RNA-seq
Funded at University of Nevada Las Vegas · NIH-11089334 · Data updated 2026-11-12
This study is looking at how different ways genes can be spliced affect how cells work, using a special technique to look at individual cells, and it aims to create better methods for understanding how cells grow and change, which could help us learn more about diseases and development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $145,556 |
| NIH project number | 5R16GM149510-03 |
| Project ID | NIH-11089334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve cellular differentiation or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to cellular differentiation or splicing abnormalities may not benefit from this research.
What this research studies
This research investigates how alternative splicing affects gene expression in different cell types using single cell RNA sequencing (scRNA-seq). It aims to develop a new method to accurately identify splicing events that are often overlooked due to technical challenges in current scRNA-seq analysis. By comparing existing techniques and evaluating new protocols, the research seeks to enhance the understanding of how cells differentiate and develop. This could lead to improved analysis pipelines for studying various diseases and developmental processes.
Why it matters
Potential benefit: If successful, this research could provide insights into cellular differentiation and organ development, potentially leading to better diagnostic and therapeutic strategies for diseases related to splicing abnormalities.
How similar studies have gone: Other research has shown promise in improving scRNA-seq analysis techniques, but this specific approach to alternative splicing in single cells is relatively novel.
Where this research is happening
-
University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Han, Mira — University of Nevada Las Vegas
- Study coordinator: Han, Mira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.