Understanding how different cell types process RNA
Official title: Mechanisms of Cell-type-specific pre-mRNA Splicing
Funded at University of Chicago · NIH-11136515 · Data updated 2026-11-12
This study is looking at how different cells in the mouse brain control the process of making proteins, which is important for understanding how our bodies work, and it aims to uncover the unique ways each cell type does this.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $466,828 |
| NIH project number | 5R35GM152177-02 |
| Project ID | NIH-11136515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions that may be influenced by RNA splicing abnormalities.
✕Less likely to help
Patients with conditions unrelated to RNA splicing or those not affected by genetic factors may not benefit from this research.
What this research studies
This research investigates the specific mechanisms by which different types of cells regulate the splicing of pre-mRNA, which is crucial for producing proteins. Using advanced techniques like single-cell RNA sequencing and genome editing, the team aims to identify the unique patterns and regulatory elements that govern splicing in various cell types, particularly in the mouse brain. By addressing current limitations in RNA analysis, the research seeks to provide insights into how splicing varies across different cells and conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic regulation and potential therapies for diseases linked to splicing errors.
How similar studies have gone: Previous research has shown promising results in understanding RNA splicing mechanisms, but this approach aims to explore uncharted areas, making it a novel investigation.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Zhang, Xiaochang — University of Chicago
- Study coordinator: Zhang, Xiaochang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.