Understanding how different cell types in the intestine are affected by aging
Investigating the chromatin landscape of complex tissues through cell-type-specific patterns
['FUNDING_FELLOWSHIP'] · FRED HUTCHINSON CANCER CENTER · NIH-11007186
This study is looking at how aging affects the different types of cells in your intestines, which could help us understand how these changes impact gut health as we get older.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11007186 on ClinicalTrials.gov |
What this research studies
This research investigates the chromatin landscape of various cell types in the intestine to understand how aging impacts their function and identity. By generating specific chromatin profiles for intestinal stem and differentiated cells, the study aims to uncover the effects of age-related changes on gene expression and cell behavior. The methodology involves a technique called CUT&Tag, which allows for detailed analysis of chromatin modifications even with low cell numbers. This approach will help identify the unique roles of different cell types in maintaining intestinal health throughout life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related changes in intestinal health or function.
Not a fit: Patients with acute intestinal conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of age-related intestinal disorders and potential therapeutic strategies.
How similar studies have performed: Previous research has shown promise in understanding chromatin modifications in other tissues, suggesting potential for success in this novel approach.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEICHTER, SARAH — FRED HUTCHINSON CANCER CENTER
- Study coordinator: LEICHTER, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.