Understanding how different cell types in the intestine are affected by aging
Official title: Investigating the chromatin landscape of complex tissues through cell-type-specific patterns
Funded at Fred Hutchinson Cancer Center · NIH-11007186 · Data updated 2026-11-12
This study is looking at how aging affects the different types of cells in your intestines, which could help us understand how these changes impact gut health as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 5F32GM153148-02 |
| Project ID | NIH-11007186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related changes in intestinal health or function.
✕Less likely to help
Patients with acute intestinal conditions unrelated to aging may not benefit from this research.
What this research studies
This research investigates the chromatin landscape of various cell types in the intestine to understand how aging impacts their function and identity. By generating specific chromatin profiles for intestinal stem and differentiated cells, the study aims to uncover the effects of age-related changes on gene expression and cell behavior. The methodology involves a technique called CUT&Tag, which allows for detailed analysis of chromatin modifications even with low cell numbers. This approach will help identify the unique roles of different cell types in maintaining intestinal health throughout life.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of age-related intestinal disorders and potential therapeutic strategies.
How similar studies have gone: Previous research has shown promise in understanding chromatin modifications in other tissues, suggesting potential for success in this novel approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Leichter, Sarah — Fred Hutchinson Cancer Center
- Study coordinator: Leichter, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.