Understanding how different cell structures interact in health and disease
Official title: Factors and Functions of Contact Sites between Membrane-bound and Membrane-less Organelles
Funded at Baylor College of Medicine · NIH-10930947 · Data updated 2026-11-12
This study is looking at how different parts of cells, both those with membranes and those without, work together to keep the cell organized, which is important for staying healthy and understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 5R35GM151054-02 |
| Project ID | NIH-10930947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or other diseases related to cellular dysfunction.
✕Less likely to help
Patients with conditions unrelated to cellular organization or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the interactions between membrane-bound organelles, like the endoplasmic reticulum, and membrane-less organelles, such as RNA-sequestering condensates. By examining these interactions, the research aims to uncover how these organelles work together to organize the cytoplasm, which is crucial for cell function. The approach includes both in vitro and in vivo studies to explore the formation, maintenance, and disassembly of these organelle interactions. This could provide insights into cellular processes that are vital for health and may contribute to understanding diseases, particularly cancers.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular organization that may improve our understanding of cancer and other diseases.
How similar studies have gone: While this research explores novel interactions between organelles, similar studies have shown promising results in understanding cellular processes.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lee, Jason Edward — Baylor College of Medicine
- Study coordinator: Lee, Jason Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.