Understanding how different cancer cell types in pancreatic cancer respond to radiation
Official title: Cellular phenotypic heterogeneity and resistance to radiotherapy in pancreatic adenocarcinoma
Funded at Ohio State University · NIH-10918091 · Data updated 2026-11-12
This study is looking at how different types of cancer cells in pancreatic cancer respond to radiation therapy, with the hope of finding better ways to help patients get more effective treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5DP5OD031864-04 |
| Project ID | NIH-10918091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with pancreatic ductal adenocarcinoma who are undergoing or considering radiation therapy.
✕Less likely to help
Patients with other types of cancer or those who are not receiving radiation therapy may not benefit from this research.
What this research studies
This research investigates the diverse characteristics of cancer cells in pancreatic adenocarcinoma and how these differences affect their response to radiation therapy. By examining the microenvironments within tumors, the study aims to identify mechanisms that lead to resistance against treatment. The approach involves using pancreatic tumor models to explore how certain cancer cell subsets can influence the behavior of others, potentially leading to improved therapeutic strategies for patients. The ultimate goal is to enhance the effectiveness of radiation therapy for pancreatic cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation treatments for pancreatic cancer, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding cancer cell heterogeneity and its impact on treatment resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Pitter, Kenneth L — Ohio State University
- Study coordinator: Pitter, Kenneth L
Related research
Other NIH-funded projects on the same topics.
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SOAT1 as a target in pancreatic cancer
Researchers are studying a specific enzyme, SOAT1, to see if blocking it can slow down or stop pancreatic cancer progression in models that mimic human disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.