Understanding how different brain regions work together for decision-making
Official title: P5: Mechanistic Multi-Region Brain Models
Funded at Princeton University · NIH-10900690 · Data updated 2026-11-12
This study is looking at how different parts of the brain work together when we make complicated decisions, and it could help people understand and improve their thinking skills if they have trouble making choices.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $665,296 |
| NIH project number | 5U19NS132720-02 |
| Project ID | NIH-10900690 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit are individuals experiencing cognitive impairments or decision-making difficulties.
✕Less likely to help
Patients with no cognitive impairments or those not involved in decision-making processes may not receive benefit from this research.
What this research studies
This research investigates the roles of various brain areas in complex decision-making processes. By utilizing experimental data from multiple projects, the team aims to create detailed models that explain how regions like the basal ganglia and entorhinal cortex interact during evidence accumulation and decision-making tasks. Patients may benefit from insights gained about cognitive functions and potential treatments for decision-making impairments. The approach combines advanced computational modeling with experimental neuroscience to explore brain function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of cognitive disorders related to decision-making.
How similar studies have gone: Other research has shown success in understanding brain functions through similar multi-region modeling approaches, indicating a promising avenue for this investigation.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Goldman, Mark S — Princeton University
- Study coordinator: Goldman, Mark S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.