Understanding how different brain regions are affected in Lewy Body Dementia
Region-Specific Vulnerability of the Lewy Body Dementia's Brain
This study is looking at how different parts of the brain are affected in people with Lewy Body Dementia, to help us understand what causes problems with thinking and movement, and to find better treatments for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10862585 on NIH RePORTER |
What this research studies
This research investigates the specific vulnerabilities of different brain regions in patients with Lewy Body Dementia (LBD), a progressive neurodegenerative disorder. By examining the aggregation of a protein called α-synuclein and its impact on various brain areas, the study aims to uncover the mechanisms that lead to cognitive and motor dysfunction in LBD. Researchers will analyze the interactions between neurons, microglia, and astrocytes to understand how these cellular behaviors contribute to the disease's progression. This research could provide insights into targeted therapies and interventions for patients suffering from LBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy Body Dementia or those exhibiting symptoms of this condition.
Not a fit: Patients with other forms of dementia, such as Alzheimer's disease without Lewy body characteristics, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Lewy Body Dementia.
How similar studies have performed: Previous research has shown promising results in understanding neurodegenerative diseases through similar approaches, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Na, Chan-Hyun — Johns Hopkins University
- Study coordinator: Na, Chan-Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.