Understanding how different brain cells interact in Alzheimer's Disease
Systematic modeling and prediction of cell-type-specific and spatiotemporal crosstalk pathways in Alzheimer's Disease
This study is looking at how different brain cells work together in Alzheimer's Disease to find new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11085151 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between various types of brain cells in Alzheimer's Disease (AD) using advanced computational models and 3D cell cultures. By analyzing how neurons and glial cells communicate and influence each other, the study aims to uncover new pathways that contribute to the disease's progression. The approach combines single-cell transcriptomic data with 3D models to create a detailed picture of cellular interactions in the brain. This could lead to identifying new therapeutic targets for treating AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatment strategies for Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in using multi-cellular systems biology approaches to understand complex diseases, indicating potential for success in this novel application.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Wong, Stephen Tc — Methodist Hospital Research Institute
- Study coordinator: Wong, Stephen Tc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.