Understanding how different bones respond to stress in the bone marrow.
Official title: Skeletal heterogeneity of bone marrow stress responses.
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11194461 · Data updated 2026-11-12
This study is looking at how different bones in your body respond when you're under stress or dealing with illness, to help us understand how blood cells are made in those bones and how that process can change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $503,478 |
| NIH project number | 5R01DK141465-02 |
| Project ID | NIH-11194461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that impact blood cell formation, such as beta-thalassemia or those undergoing treatments that affect hematopoiesis.
✕Less likely to help
Patients with stable blood cell production and no history of hematological disorders may not benefit from this research.
What this research studies
This research investigates how bone marrow functions under stress, particularly during disease, by examining the responses of various bones rather than just focusing on long bones. The study aims to uncover the cellular mechanisms that lead to different responses in bone marrow depending on the specific bone being analyzed. By exploring how factors like hemorrhage and treatment with G-CSF affect blood cell production in different bones, the research seeks to provide insights into the unique roles of each bone's microenvironment in hematopoiesis. This could lead to a better understanding of blood cell formation and its regulation during stress.
Why it matters
Potential benefit: If successful, this research could improve treatment strategies for conditions affecting blood cell production and enhance recovery after hematological stress.
How similar studies have gone: While the approach of examining multiple bones for hematopoiesis is less common, previous studies have shown that localized responses in bone marrow can vary, suggesting potential for success in this novel investigation.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Lucas, Daniel — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lucas, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.