Understanding how different blood stem cells develop
Dissecting heterogeneity in hematopoietic stem and progenitor cell ontogeny
This work helps us learn how different types of blood-forming cells develop from the very beginning, which is key to understanding blood diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11143304 on NIH RePORTER |
What this research studies
Our bodies rely on special blood stem cells and other early blood cells to create all the different blood components we need throughout life. This work explores how these important cells form and mature during early development. We are using zebrafish models to observe these cells in their natural environment, which helps us see how they truly function. By understanding these early processes, we hope to uncover why some people develop blood-related conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals affected by various blood diseases in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of blood diseases and potentially new ways to treat them by targeting the origins of these conditions.
How similar studies have performed: Previous studies have shown discrepancies between laboratory and natural environment assessments of blood cell function, highlighting the novelty and importance of this approach.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Bowman, Teresa V — Albert Einstein College of Medicine
- Study coordinator: Bowman, Teresa V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.