Understanding how different bacteria interact to affect antibiotic effectiveness
Mapping polymicrobial interactions that modulate antibiotic persistence
This study looks at how different bacteria and their surroundings help some germs, like Staphylococcus aureus, survive even when antibiotics are used, with the goal of finding better ways to treat infections that can be tough to beat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10879805 on NIH RePORTER |
What this research studies
This research investigates how interactions between various bacteria and environmental factors influence the ability of certain bacteria to survive antibiotic treatment. By examining the responses of Staphylococcus aureus in the presence of other microbes, the study aims to uncover mechanisms that allow some bacteria to persist despite antibiotic therapy. The approach involves co-culturing bacteria to observe their behavior and responses under different conditions, which could lead to improved treatment strategies for infections. Patients may benefit from insights gained that could help in developing more effective antibiotic regimens.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with recurrent or chronic bacterial infections, particularly those caused by Staphylococcus aureus.
Not a fit: Patients with infections caused by bacteria that are not Staphylococcus aureus or those who do not have recurrent infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bacterial infections, reducing the incidence of treatment failures and chronic infections.
How similar studies have performed: Other research has shown promise in understanding bacterial interactions and antibiotic resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Mok, Wendy W.k. — University of Connecticut Sch of Med/dnt
- Study coordinator: Mok, Wendy W.k.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.