Understanding how different bacteria and host responses affect tuberculosis
Bacterial and Host Heterogeneity in TB latency, persistence and progression
This study is looking at how the bacteria that cause tuberculosis interact with our immune system to see why some people get sick while others don’t, and it needs patients to help by sharing samples or information to find out more about treatment challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10874586 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the bacteria that cause tuberculosis (TB) and the human immune system. It aims to uncover how variations in both the bacteria and the host can lead to different outcomes in TB infections, including latency, persistence, and progression to active disease. By analyzing genetic and phenotypic differences, the study seeks to identify factors that contribute to drug resistance and treatment failures. Patients may be involved in providing samples or data to help researchers understand these interactions better.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with tuberculosis, especially those experiencing complications or treatment failures.
Not a fit: Patients who have never been diagnosed with tuberculosis or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and management strategies for tuberculosis, particularly for those with drug-resistant strains.
How similar studies have performed: Previous research has shown promising results in understanding the heterogeneity of TB, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Alland, David — Rutgers Biomedical and Health Sciences
- Study coordinator: Alland, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.